Development of novel antifungals

Antimicrobial resistance (AMR) represents a major threat to global public health care systems. The World Health Organization has predicted 10 million AMR-related deaths annually by 2050 if no drastic measures are taken.

Antifungal resistance is emerging as a major threat, and we urgently need to develop new antifungals that are not susceptible to current resistance mechanisms. This project will build on a longstanding collaboration with Neoculi Pty Ltd to identify new antifungal leads and develop existing leads as antifungal drugs through established pathways for laboratory-based efficacy testing, characterisation of modes of action and testing of efficacy in relevant in vivo models.